Technology

Our approach is based on liquid chromatography coupled mass spectrometry (LC-MS)—a tried-and-true analytical instrument used widely in modern clinical and research laboratories around the world. We focus primarily on harnessing the powerful capabilities of modern high-frequency, high-resolution mass spectrometers.

At Dalton Bioanalytics, we have developed innovative laboratory and computational techniques that enable us to measure nearly all types of molecules in a one-shot analysis—dramatically cutting the costs and complications associated with current multiomics methods. For example, in human plasma we can concurrently identify and quantify thousands of analytes including proteins, lipids, electrolytes, and small molecules, essentially condensing the breadth of 4+ specialized laboratories into a single run (proteomics, lipidomics, metallomics, metabolomics, etc.).

Spectrogram of our multi-omic analysis in human plasma. Each colored speck is a unique molecular feature with increasing signal intensity being expressed from red to blue (interpretation is analogous to a 2-D gel). Retention time and mass-to-charge ratio are on the horizontal and vertical axes, respectively. The spectrogram animation zooms in and out along the m/z axis to visualize the capture of diverse biochemicals including polar lipids, electrolytes, metabolites, proteins, and nonpolar lipids (e.g. phosphatidylcholine, glucose, apolipoprotein A, and cholesterol, respectively).

Using our technology, we aim to simplify multiomic analysis for the scientific community, better empowering them to make important discoveries across all domains of biomedical research.

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Dalton Bioanalytics

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